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藥靶細(xì)胞株 > kinase激酶細(xì)胞株 > CBP73181EGFR S768_V769delinsIL（S768I/V769L）/BaF3

EGFR S768_V769delinsIL（S768I/V769L）/BaF3
名稱 EGFR S768_V769delinsIL（S768I/V769L）/BaF3
型號(hào) CBP73181
報(bào)價(jià)
特點(diǎn) EGFR S768_V769delinsIL（S768I/V769L）/BaF3,母細(xì)胞：BaF3，凍存條件：90% FBS+10% DMSO
  • 詳細(xì)內(nèi)容
CBP73181
I. Introduction

Cell Line Name：

EGFR S768_V769delinsIL(S768I&V769L)/BaF3

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS+2ug/ml puromycin

Mycoplasma Status:

Negative

II.Background

EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. EGFR S768_V769delinsIL results in a deletion of two amino acids in the protein kinase domain of the Egfr protein from aa 768 to aa 769, combined with the insertion of an isoleucine (I) and a leucine (L) at the same site (UniProt.org). S768_V769delinsIL has been identified in the scientific literature (PMID: 17045698, PMID: 27304188), but has not been biochemically characterized and therefore, its effect on Egfr protein function is unknown (PubMed, Jul 2019).

III. Representative Data

1. WB of EGFR S768_V769delinsIL(S768I&V769L)/BaF3

CBP73181.jpg

2. Anti-proliferation assay


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